BRCA Biomarkers
PLOS Papers on Orofacial Cleft Genetics, BRCA1/2 in Prostate Cancer in Morocco, More
In PLOS this week: genetic contributors to cleft palate-related conditions, role of BRCA mutations in prostate cancer in Morocco, and more.
Lynparza Benefit in Early BRCA-Mutated Breast Cancer Reignites Universal Genetic Testing Discussion
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The OlympiA trial showed a disease-free survival benefit with adjuvant PARP inhibitor therapy for early-stage, BRCA1/2-mutated, HER2-negative breast cancer patients.
For Reduced Recurrences
According to the Guardian, a new study suggests treatment with a PARP inhibitor may decrease recurrences in hereditary breast cancer.
BRCA2 Variants of Unknown Significance Reclassified Through Functional Data Additions
Researchers reclassified 86 percent of variants initially determined to be VUS, potentially changing surveillance or treatment approaches for patients.
Breast Cancer Risk Gene Associations Refined in Large-Scale Studies
Two new studies revealed the prevalence of pathogenic variants in breast cancer-related genes, while highlighting genes that may be most informative in the clinic.