BRCA Biomarkers News and reporting on BRCA biomarkers. Lynparza Benefit in Early BRCA-Mutated Breast Cancer Reignites Universal Genetic Testing Discussion Premium The OlympiA trial showed a disease-free survival benefit with adjuvant PARP inhibitor therapy for early-stage, BRCA1/2-mutated, HER2-negative breast cancer patients. BRCA2 Variants of Unknown Significance Reclassified Through Functional Data Additions Researchers reclassified 86 percent of variants initially determined to be VUS, potentially changing surveillance or treatment approaches for patients. Breast Cancer Risk Gene Associations Refined in Large-Scale Studies Two new studies revealed the prevalence of pathogenic variants in breast cancer-related genes, while highlighting genes that may be most informative in the clinic. MSK Study Suggests Germline Tests May Miss Mosaic Cancer Risk Mutations in Some Patients Premium Using tumor and matched normal sequence data generated for tens of thousands of cancer patients, the team identified mosaic cancer susceptibility in around one in 1,000 cases. Invitae Launches Study to Explore Impact of Testing Guidelines on Prostate Cancer Patients' Outcomes The nationwide study will enroll prostate cancer patients who do and don't meet current guidelines and assess how access to genetic information impacts their care. Jul 27, 2020 Genetic Screening Identifies Many at Risk of Inherited Disease But Missed by Routine Care Jul 17, 2020 BRCA1/2 Population Screening Predicted to be Cost-Effective in Countries With Different Income Levels Jul 10, 2020 Study Sees Survival Boost For BRCA1/2 Carriers Tested Before Breast Cancer Diagnosis Jul 1, 2020 Polygenic Risk Score Modifies Breast Cancer Risk in Pathogenic Variant Carriers Jun 10, 2020 Cancer Experts Develop Precision Medicine-Based Genetic Testing Framework for Prostate Cancer Jun 4, 2020 Studies Show Potential of Video, Online Education to Expand Cancer Risk Genetic Test Access Premium May 31, 2020 Germline Results From Tumor-Normal Sequencing Guides Precision Therapy in Advanced Cancer Patients May 20, 2020 FDA Approves Lynparza With Myriad, Foundation Med CDx Tests in HRR-Mutated Prostate Cancer May 11, 2020 FDA Approves Lynparza/Avastin With Myriad Genetics CDx for Platinum-Sensitive Ovarian Cancer Apr 30, 2020 GSK Gets Broad Zejula Indication in Ovarian Cancer; FDA Deems Myriad Genetics' Test Complementary Apr 6, 2020 Myriad Genetics BRCA Test to be Reimbursed in Japan Feb 11, 2020 Myriad Files sPMA With FDA for Test to ID Best Responders to Lynparza, Avastin Combination Jan 29, 2020 Breast Cancer Risk Clues Found By Sequencing Cells From BRCA2 Germline Mutation Carriers Jan 21, 2020 Myriad Genetics Files for FDA Approval of BRACAnalysis CDx for Lynparza in Prostate Cancer Jan 8, 2020 Researchers Identify Breast Cancer Target Genes Via Fine-Mapping of Disease Risk Regions Dec 30, 2019 FDA Approves AstraZeneca's Lynparza, Myriad Genetics' CDx for BRCA-Positive Pancreatic Cancer Dec 12, 2019 Universal Genetic Testing in Breast Cancer May Result in More Harm Than Good, Experts Worry Premium Dec 12, 2019 ACMG Suggests Docs Evaluate All Breast Cancer Patients for Genetic Risk Test Suitability Dec 4, 2019 NCCN Updates Genetic Testing Guidelines for Assessing Breast, Ovarian, Pancreatic Cancer Risk Nov 21, 2019 Myriad Genetics BRACAnalysis Approved by Japanese Regulators Load More Breaking News Pediatric Medulloblastoma Subgroups May Benefit from Lower-Dose Radiation Therapy Space Radiation Shows Limited Effects on Mammalian Sperm DNA, Fertility Bluestar Genomics Sues Former Consultant, Ludwig Institute for Cancer Research Over IP Ownership New Products Posted to GenomeWeb: 10x Genomics, Swift Biosciences, Agilent Technologies, More In Brief This Week: Quantum-Si, TGen, Yale, and More People in the News: New Appointments at Invitae, PGDx, Oxford Nanopore, PacBio, More The Scan Fertility Fraud Found Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today. Ties Between Vigorous Exercise, ALS in Genetically At-Risk People Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports. Test Warning The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK. Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.