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BRAF Biomarkers

News and reporting on BRAF biomarkers.

NCCN Publishes First Guidelines for Pediatric Brain Cancer, Recommends Broad NGS Profiling

The guidelines recognize the importance of molecular profiling in diagnosing, treating, and identifying clinical trial opportunities for children with high-grade gliomas. 

Kinnate Biopharma, Guardant Health Partner for Study of BRAF Mutations in Solid Tumors

Preliminary findings indicate that about half of the 6,000 patients with BRAF alteration-positive cancers harbored Class II and III alterations.

MapKure, Personalis Partner to Screen Patients for BRAF Inhibitor Trial

Personalis plans to develop a companion diagnostic to MapKure's BRAF inhibitor, BGB-3245, once biomarkers have been identified in the study.

Novellus, Tempus Partner to Enroll Patients in BRAF Inhibitor Clinical Trial Program

The Jerusalem-based drug developer is studying PLX8394 in patients with BRAF V600-mutated gliomas and solid tumors with non-V600 mutations. 

Melanoma Treatment Stage Affects Ability of Liquid Biopsy to Predict Immunotherapy Benefit
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Researchers showed that ctDNA levels predicted who would respond to first-line immune checkpoint inhibition but were not useful in second-line therapy.

Jul 29, 2020

Strata Oncology, BioMed Valley Discoveries Partner on Patient Enrollment for Ulixertinib Study

Apr 27, 2020

Amid COVID-19, Lower Cancer Diagnosis Rates Mean Fewer Patients Getting Molecular Tests, Treatment
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Feb 13, 2020

Genetron Health Obtains Regulatory Approval in China for NGS Instrument, Lung Cancer Panel

Jan 27, 2020

Colon Cancer Biomarker Undertesting Rates in Real-World Data Points to Precision Oncology Barriers
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Sep 23, 2019

Global Survey Reveals Suboptimal Molecular Testing Access in Lung Cancer Despite Broad Guidelines
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Jun 18, 2019

Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms
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Jun 6, 2019

TAPUR Study Investigators Report First Positive Findings, Pursuing Tissue-Agnostic Cohorts
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May 16, 2019

NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy
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May 9, 2019

Liquid Biopsy of Melanoma Surgery Drainage Fluid Shows Promise for Recurrence Monitoring
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Jan 25, 2019

MethylDetect Looks to Leverage High-Resolution Melt Tech for Oncology Assay Development
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Jan 10, 2019

Melanoma BRAF Mutation Type May Affect Response to Targeted Treatments, Immunotherapy

Aug 7, 2018

Researchers Integrate Genotyping Assay, Drug Delivery Tech for Precision Glioma Treatment
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Jun 18, 2018

Recurrent Rearrangements Identified in Rare Infant Soft Tissue Tumors

May 31, 2018

PanDrugs System Aims to Advance Precision Cancer Care by Matching Treatments to Mutations
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Nov 6, 2017

Genentech's Zelboraf Gets FDA Approval in BRAF Mutation-Positive Erdheim-Chester Disease

Jun 22, 2017

Thermo Fisher Next-Gen Sequencing Panel Wins FDA Approval as Companion Test

Jun 22, 2017

Quest Diagnostics to Expand Advanced Cancer Care to Community Oncologists Through Recent Acquisitions
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May 1, 2017

BRAF Proficiency Testing Reporting Adequate But Could Improve, Analysis Finds

Feb 16, 2017

Head-to-Head Comparison of BRAF Assays Yields Clues About Ideal Use in Guiding Melanoma Therapy
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Dec 15, 2016

Biocartis Gets CE Mark for Idylla NRAS-BRAF Mutation Test

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The Scan

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.

Clinical Trial Participants, Investigators Point to Importance of Clinical Trial Results Reporting in Canadian Study

Public reporting on clinical trial results is crucial, according to interviews with clinical trial participants, investigators, and organizers from three provinces appearing in BMJ Open.

Old Order Amish Analysis Highlights Autozygosity, Potential Ties to Blood Measures

Researchers in BMC Genomics see larger and more frequent runs-of-homozygosity in Old Order Amish participants, though only regional autozygosity coincided with two blood-based measures.

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.