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BRAF Biomarkers

News and reporting on BRAF biomarkers.

MapKure, Personalis Partner to Screen Patients for BRAF Inhibitor Trial

Personalis plans to develop a companion diagnostic to MapKure's BRAF inhibitor, BGB-3245, once biomarkers have been identified in the study.

Novellus, Tempus Partner to Enroll Patients in BRAF Inhibitor Clinical Trial Program

The Jerusalem-based drug developer is studying PLX8394 in patients with BRAF V600-mutated gliomas and solid tumors with non-V600 mutations. 

Melanoma Treatment Stage Affects Ability of Liquid Biopsy to Predict Immunotherapy Benefit
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Researchers showed that ctDNA levels predicted who would respond to first-line immune checkpoint inhibition but were not useful in second-line therapy.

Strata Oncology, BioMed Valley Discoveries Partner on Patient Enrollment for Ulixertinib Study

Through the partnership, Strata will use its next-generation sequencing test to identify advanced cancer patients with mutations in the MAPK signaling pathway.

Amid COVID-19, Lower Cancer Diagnosis Rates Mean Fewer Patients Getting Molecular Tests, Treatment
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Data amassed by analytics firm Diaceutics suggests fewer patients are coming into healthcare facilities and missing the chance for diagnosis, molecular testing, and treatment.

Feb 13, 2020

Genetron Health Obtains Regulatory Approval in China for NGS Instrument, Lung Cancer Panel

Jan 27, 2020

Colon Cancer Biomarker Undertesting Rates in Real-World Data Points to Precision Oncology Barriers
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Sep 23, 2019

Global Survey Reveals Suboptimal Molecular Testing Access in Lung Cancer Despite Broad Guidelines
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Jun 18, 2019

Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms
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Jun 6, 2019

TAPUR Study Investigators Report First Positive Findings, Pursuing Tissue-Agnostic Cohorts
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May 16, 2019

NCI Pediatric MATCH Trial Interim Data Shows 24 Percent of Patients Eligible for Targeted Therapy
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May 9, 2019

Liquid Biopsy of Melanoma Surgery Drainage Fluid Shows Promise for Recurrence Monitoring
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Jan 25, 2019

MethylDetect Looks to Leverage High-Resolution Melt Tech for Oncology Assay Development
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Jan 10, 2019

Melanoma BRAF Mutation Type May Affect Response to Targeted Treatments, Immunotherapy

Aug 7, 2018

Researchers Integrate Genotyping Assay, Drug Delivery Tech for Precision Glioma Treatment
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Jun 18, 2018

Recurrent Rearrangements Identified in Rare Infant Soft Tissue Tumors

May 31, 2018

PanDrugs System Aims to Advance Precision Cancer Care by Matching Treatments to Mutations
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Nov 6, 2017

Genentech's Zelboraf Gets FDA Approval in BRAF Mutation-Positive Erdheim-Chester Disease

Jun 22, 2017

Thermo Fisher Next-Gen Sequencing Panel Wins FDA Approval as Companion Test

Jun 22, 2017

Quest Diagnostics to Expand Advanced Cancer Care to Community Oncologists Through Recent Acquisitions
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May 1, 2017

BRAF Proficiency Testing Reporting Adequate But Could Improve, Analysis Finds

Feb 16, 2017

Head-to-Head Comparison of BRAF Assays Yields Clues About Ideal Use in Guiding Melanoma Therapy
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Dec 15, 2016

Biocartis Gets CE Mark for Idylla NRAS-BRAF Mutation Test

Sep 6, 2016

Combined PNA Clamp, Sensor PCR Method Shows Promise for Detection of BRAF Mutations
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Aug 8, 2016

BRAF Inhibitor Resistance Mutations Identified

Breaking News
The Scan

Renewed Gain-of-Function Worries

The New York Times writes that the pandemic is renewing concerns about gain-of-function research.

Who's Getting the Patents?

A trio of researchers has analyzed gender trends in biomedical patents issued between 1976 and 2010 in the US, New Scientist reports.

Other Uses

CBS Sunday Morning looks at how mRNA vaccine technology could be applied beyond SARS-CoV-2.

PLOS Papers Present Analysis of Cervicovaginal Microbiome, Glycosylation in Model Archaea, More

In PLOS this week: functional potential of the cervicovaginal microbiome, glycosylation patterns in model archaea, and more.