BCR-ABL

The assay improves upon other tests by attaining a sensitivity of MR4.7 while it allows direct reporting on the IS, Asuragen said.

NEW YORK (GenomeWeb) — Using PCR-based methods to detect mutations in the BCR-ABL1 kinase domain of chronic myeloid leukemia patients has been established as a critical tool for monitoring CML patient response to tyrosine kinase inhibitor therapy.

Quidel said this week that it has received 510(k) clearance from the US Food and Drug Administration for its Quidel Molecular RSV + hMPV assay for the detection of respiratory syncytial virus and human metapneumovirus.

Monoquant, an Australian company spun out of Flinders University to commercialize molecular methods to monitor minimal residual disease in blood cancers, has developed a PCR-based DNA assay that can routinely detect one cancerous cell in 10 million normal cells in chronic myeloid

The US Food and Drug Administration has approved Pfizer's Bosulif (bosutinib) as a treatment for chronic, accelerated, or blast-phase Philadelphia chromosome-positive chronic myelogenous leukemia for patients who are resistant or intolerant to other treatments, such as Novartis'

Cepheid Launches Standardized Xpert BCR-ABL Monitor Test
Cepheid has released an updated version of its Xpert BCR-ABL Monitor test, which now incorporates "lot-specific standardization" based on World Health Organization BCR-ABL guidelines.

FDA Grants Standard Review for Pfizer's NDA for Bosutinib in Ph-Positive CML

This article has been updated from a previous version to include information on the filing status of lumiracoxib in Europe, to clarify the current indication for nilotinib, and to correct information about the company's BCR-ABL development partners.

Medco will offer MolecularMD's qRT-PCR BCR-ABL test to patients diagnosed with chronic myeloid leukemia in order to monitor their response to tyrosine kinase inhibitors such as Gleevec, Sprycel, and Tasigna.

Roche and Clovis Oncology to develop PCR-based companion IVD for EGFR mutations; Medco Health to offer MolecularMD's qRT-PCR test for BCR-ABL.

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In an against-all-odds twist, a researcher studying exceeding rare FOXG1 mutations discovers her daughter has the syndrome.

An effort by Genomics Medicine Ireland is creating a database of diseases based on the genomics of people in Ireland. It now is looking into the possibility of including Scotland in its work.

In recent weeks, the direct-to-consumer genetics firm has rolled out a health hub where customers can share information concerning 18 common health conditions.

In PLOS this week, new genes associated with prostate cancer risk, genetic patterns in M. bovis, and more.