APOE4

By combining iPSCs, CRISPR gene editing, and transcriptomic approaches, researchers examined the effects of an Alzheimer's disease risk variant on brain cells.

The model aims to uncover stroke patients at high, medium, or low risk of cerebral amyloid angiopathy, which is linked to additional strokes or dementia.

Researchers sequenced the APOE gene in over 900 individuals, finding supporting evidence for the APOE2 allele's role in longevity and lower levels of lipids.

A team led by Buck Institute for Research on Aging scientists has reported that ApoE4 binds the promoter regions of Alzheimer's disease genes, including SirT1.

The evidence-based "Choosing Wisely" suggestions are meant to facilitate conversation between doctors and patients about unnecessary and wasteful interventions.

The group demonstrated the ability of a genetic algorithm to gauge whether cognitively normal people are at risk of near-term mental decline.

Originally published May 22.
Genentech is planning to study whether the investigational drug crenezumab can prevent Alzheimer's in a patient population genetically predisposed to get the degenerative disease.

"We are always looking at entities, particularly DTC companies, who may be marketing APOE tests without a sublicense from Athena, are making misleading representations of those tests and their clinical interpretations, and are generally violating patent claims we own and have licensed, accordingly," said a Duke spokesperson.

The "opt-in" model ensures that customers are aware of the risks and limitations of this potentially sensitive data, but some are questioning whether the direct-to-consumer model is the appropriate mechanism for delivering information on APOE status, even with additional precautions.

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The Wall Street Journal reports Human Longevity's valuation has dropped by 80 percent.

The New York Times and ProPublica say that many physicians fail to disclose their financial ties when publishing in medical journals.

Science reports that the US National Cancer Institute is cutting its operating budget by 5 percent.

In PLOS this week: similar variants seen in bullbogs, people with Robinow syndrome; ApoE genotypes in African-American, Puerto Rican populations; and more.