APOE4 Genetic Risk of Cognitive Decline Varies Between Latino Populations, Study Finds The APOE-ε4 allele, a major genetic risk factor for Alzheimer's disease, conveys more risk among Cuban than other Latino populations, the analysis found. Alzheimer's Disease Risk Linked to Noncoding Variants in APOE Region The researchers not only tied a variant near TOMM40 to Alzheimer's disease, but also two variants not previously implicated in risk for the disease. NIH Grants $4.8M for Mulit-Omic Study of ApoE4 in Alzheimer's Disease Gladstone Institutes researchers will use proteomic, genomic, and gene-altering approaches to investigate apoe4 toxicity as part of a five-year project. Alzheimer's Disease Potential Risk Variants Identified in Study of APOE4 Carriers, Noncarriers Using exome data from Alzheimer's disease cases and controls with or without the APOE4 risk allele, investigators identified potential risk-stratifying variants. Functional Characterization of Alzheimer's Disease APOE4 Variant Shows How it Changes Brain Cells By combining iPSCs, CRISPR gene editing, and transcriptomic approaches, researchers examined the effects of an Alzheimer's disease risk variant on brain cells. Jan 11, 2018 Combined Genotyping, CT Scan Model Predicts Risk of Stroke Recurrence Mar 3, 2016 APOE Sequencing Confirms Previous Markers of Longevity, Implicates Regulatory Variants Jan 20, 2016 Alzheimer's-Related ApoE4 Acts as Transcription Factor to Lead to Disease Jul 24, 2015 ACMG Recommendations Aim to Spark Physician, Patient Discussion on Genetic Testing Premium Jul 21, 2015 Duke Researchers Present New Data on APOE/TOMM40 Algorithm for Alzheimer's MCI Risk Premium Jul 25, 2012 Rodent Study Suggests Low-Dose Pioglitazone May Improve Cognitive Function in Alzheimer's Patients Premium May 23, 2012 Genentech Takes Personalized Medicine Approach in Pursuing Amyloid Hypothesis for Alzheimer's Drug Premium Apr 27, 2011 Duke University Keeping an Eye on DTC Genomics Firms that Might be Infringing its APOE Patents Premium Apr 20, 2011 Adding Alzheimer's Risk Option, 23andMe Revives Questions on Utility of DTC Genomics Premium Jan 12, 2011 Takeda to Use Zinfandel's TOMM40 Test in Alzheimer's Development Program for Actos Premium Jul 14, 2010 Brain Imaging, Cognitive Evaluation Link TOMM40 Alterations to Alzheimer's Risk in Healthy Patients Premium Jan 6, 2010 Researchers Publish Data on Gene Variant Associated with Late-Onset Alzheimer's Disease Premium Sep 9, 2009 Avey Leaves 23andMe to Start Alzheimer's Research Foundation Using DTC Genomics Firm's Platform Premium Jul 15, 2009 Accera Presents New Pharmacogenomics Data on Medical Food Product for Alzheimer's Disease Premium Breaking News Lunaphore Technologies, University of Bern Partner on Colorectal Cancer Study People in the News: New Appointments at Biocept, Novacyt, Centogene, Illumina, More In Brief This Week: Sophia Genetics, Twist Bioscience, Dante Labs, MGI, Codex DNA, More New Products Posted to GenomeWeb: SpeeDx, Bio-Techne, NuProbe, More DiaSorin Q2 Revenues Rise 20 Percent on SARS-CoV-2 Testing Demand Cepheid Gets $28M From BARDA for SARS-CoV-2 Tests The Scan Interfering With Invasive Mussels The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels. Participation Analysis A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports. Right Whales' Decline A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC. Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.