APOE4
APOE Missense Variant Linked to Increased Alzheimer's Disease Risk in African Americans
A case-control study found that the APOE ε3[R145C] variant, seen in 4 percent of African Americans, increases AD risk in individuals with the ε3/ε4 genotype.
Protective, Risk-Linked APOE Alleles Affect Glial Cell Transcriptome
The APOEε4 allele is linked to the upregulation of a phagocytosis and proinflammatory gene set both in normal aging and Alzheimer's disease brains.
Genetic Risk of Cognitive Decline Varies Between Latino Populations, Study Finds
The APOE-ε4 allele, a major genetic risk factor for Alzheimer's disease, conveys more risk among Cuban than other Latino populations, the analysis found.
Alzheimer's Disease Risk Linked to Noncoding Variants in APOE Region
The researchers not only tied a variant near TOMM40 to Alzheimer's disease, but also two variants not previously implicated in risk for the disease.
NIH Grants $4.8M for Mulit-Omic Study of ApoE4 in Alzheimer's Disease
Gladstone Institutes researchers will use proteomic, genomic, and gene-altering approaches to investigate apoe4 toxicity as part of a five-year project.