APOE4
Genetic Risk of Cognitive Decline Varies Between Latino Populations, Study Finds
The APOE-ε4 allele, a major genetic risk factor for Alzheimer's disease, conveys more risk among Cuban than other Latino populations, the analysis found.
Alzheimer's Disease Risk Linked to Noncoding Variants in APOE Region
The researchers not only tied a variant near TOMM40 to Alzheimer's disease, but also two variants not previously implicated in risk for the disease.
NIH Grants $4.8M for Mulit-Omic Study of ApoE4 in Alzheimer's Disease
Gladstone Institutes researchers will use proteomic, genomic, and gene-altering approaches to investigate apoe4 toxicity as part of a five-year project.
Alzheimer's Disease Potential Risk Variants Identified in Study of APOE4 Carriers, Noncarriers
Using exome data from Alzheimer's disease cases and controls with or without the APOE4 risk allele, investigators identified potential risk-stratifying variants.
Functional Characterization of Alzheimer's Disease APOE4 Variant Shows How it Changes Brain Cells
By combining iPSCs, CRISPR gene editing, and transcriptomic approaches, researchers examined the effects of an Alzheimer's disease risk variant on brain cells.