APOE4 Protective, Risk-Linked APOE Alleles Affect Glial Cell Transcriptome The APOEε4 allele is linked to the upregulation of a phagocytosis and proinflammatory gene set both in normal aging and Alzheimer's disease brains. Genetic Risk of Cognitive Decline Varies Between Latino Populations, Study Finds The APOE-ε4 allele, a major genetic risk factor for Alzheimer's disease, conveys more risk among Cuban than other Latino populations, the analysis found. Alzheimer's Disease Risk Linked to Noncoding Variants in APOE Region The researchers not only tied a variant near TOMM40 to Alzheimer's disease, but also two variants not previously implicated in risk for the disease. NIH Grants $4.8M for Mulit-Omic Study of ApoE4 in Alzheimer's Disease Gladstone Institutes researchers will use proteomic, genomic, and gene-altering approaches to investigate apoe4 toxicity as part of a five-year project. Alzheimer's Disease Potential Risk Variants Identified in Study of APOE4 Carriers, Noncarriers Using exome data from Alzheimer's disease cases and controls with or without the APOE4 risk allele, investigators identified potential risk-stratifying variants. May 31, 2018 Functional Characterization of Alzheimer's Disease APOE4 Variant Shows How it Changes Brain Cells Jan 11, 2018 Combined Genotyping, CT Scan Model Predicts Risk of Stroke Recurrence Mar 3, 2016 APOE Sequencing Confirms Previous Markers of Longevity, Implicates Regulatory Variants Jan 20, 2016 Alzheimer's-Related ApoE4 Acts as Transcription Factor to Lead to Disease Jul 24, 2015 ACMG Recommendations Aim to Spark Physician, Patient Discussion on Genetic Testing Premium Jul 21, 2015 Duke Researchers Present New Data on APOE/TOMM40 Algorithm for Alzheimer's MCI Risk Premium Jul 25, 2012 Rodent Study Suggests Low-Dose Pioglitazone May Improve Cognitive Function in Alzheimer's Patients Premium May 23, 2012 Genentech Takes Personalized Medicine Approach in Pursuing Amyloid Hypothesis for Alzheimer's Drug Premium Apr 27, 2011 Duke University Keeping an Eye on DTC Genomics Firms that Might be Infringing its APOE Patents Premium Apr 20, 2011 Adding Alzheimer's Risk Option, 23andMe Revives Questions on Utility of DTC Genomics Premium Jan 12, 2011 Takeda to Use Zinfandel's TOMM40 Test in Alzheimer's Development Program for Actos Premium Jul 14, 2010 Brain Imaging, Cognitive Evaluation Link TOMM40 Alterations to Alzheimer's Risk in Healthy Patients Premium Jan 6, 2010 Researchers Publish Data on Gene Variant Associated with Late-Onset Alzheimer's Disease Premium Sep 9, 2009 Avey Leaves 23andMe to Start Alzheimer's Research Foundation Using DTC Genomics Firm's Platform Premium Jul 15, 2009 Accera Presents New Pharmacogenomics Data on Medical Food Product for Alzheimer's Disease Premium Breaking News UBS Initiates Coverage of 10X Genomics, PacBio, Akoya Biosciences, NanoString Technologies Circadian Gene Expression Variation Across Tissue Types May Offer Aging, Disease Clues Siemens Healthineers Q1 Dx Revenues Fall 21 Percent; Firm Strikes Lab Analyzer Deal With Unilabs Becton Dickinson Fiscal Q1 Revenues Down 3 Percent; Firm Raises FY23 Guidance NanoString Technologies, Weill Cornell Medicine Collaborate on Spatial Atlas of Human Tissues The Scan White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans. Study Points to Benefits of Local Consolidative Therapy, Targeted Treatments in Cancer Care In JCO Precision Oncology, researchers report that local consolidative therapy combined with molecularly targeted treatments could improve survival for some lung cancer patients. Genetic Variants That Lower LDL Cholesterol Linked to Reduced Heart Disease Risk Rare variants in two genes that lower LDL cholesterol are also associated with a decreased risk of coronary heart disease, according to a new JAMA Cardiology study. Study Links Evolution of Longevity, Social Organization in Mammals With the help of comparative phylogenetics and transcriptomics, researchers in Nature Communications see ties between lifespan and social organization in mammals.