APOE3
Qiagen, Eli Lilly Collaborate on Alzheimer's Risk Dx Panel
The firms will develop a multiplex PCR panel for the QiaStat-Dx system that detects APOE genotypes.
Dominant Alzheimer's Disease Delayed in Individuals Heterozygous for Protective APOE3 Variant
Researchers saw a protective effect in a Colombian cohort with autosomal dominant Alzheimer's disease for those who were heterozygous for the APOE3 Christchurch variant.
Late-Onset Alzheimer's Disease Features Thwarted by Protective Variant
A homozygous version of the Christchurch variant appeared to reduce disease-related features in mouse models and cells containing a late-onset Alzheimer's-linked APOE4 mutation.
Alzheimer's Disease Study Traces Factors Affecting APOE Variant Risk, Protective Effects
Researchers analyzed genetic and other data for almost 68,800 individuals to better understand ancestry, sex, and age interactions with risky and protective APOE genotypes.
APOE Missense Variant Linked to Increased Alzheimer's Disease Risk in African Americans
A case-control study found that the APOE ε3[R145C] variant, seen in 4 percent of African Americans, increases AD risk in individuals with the ε3/ε4 genotype.