APOE3 Protective, Risk-Linked APOE Alleles Affect Glial Cell Transcriptome The APOEε4 allele is linked to the upregulation of a phagocytosis and proinflammatory gene set both in normal aging and Alzheimer's disease brains. Genetic Risk of Cognitive Decline Varies Between Latino Populations, Study Finds The APOE-ε4 allele, a major genetic risk factor for Alzheimer's disease, conveys more risk among Cuban than other Latino populations, the analysis found. Alzheimer's Disease Risk Linked to Noncoding Variants in APOE Region The researchers not only tied a variant near TOMM40 to Alzheimer's disease, but also two variants not previously implicated in risk for the disease. Early-Onset Alzheimer's Mutation May Be Mitigated by APOE Variant The findings suggest a potential avenue to treat or prevent Alzheimer's disease, the researchers said. Functional Characterization of Alzheimer's Disease APOE4 Variant Shows How it Changes Brain Cells By combining iPSCs, CRISPR gene editing, and transcriptomic approaches, researchers examined the effects of an Alzheimer's disease risk variant on brain cells. Mar 3, 2016 APOE Sequencing Confirms Previous Markers of Longevity, Implicates Regulatory Variants Apr 20, 2011 Adding Alzheimer's Risk Option, 23andMe Revives Questions on Utility of DTC Genomics Premium Jan 12, 2011 Takeda to Use Zinfandel's TOMM40 Test in Alzheimer's Development Program for Actos Premium Jul 14, 2010 Brain Imaging, Cognitive Evaluation Link TOMM40 Alterations to Alzheimer's Risk in Healthy Patients Premium Jan 6, 2010 Researchers Publish Data on Gene Variant Associated with Late-Onset Alzheimer's Disease Premium Breaking News New Method Generates High-Resolution Transcriptome-Wide Spatial Gene Expression Maps GE Healthcare, University of Cambridge Team on AI-Based Precision Oncology Qiagen Sued for Allegedly Infringing Patent With Wi-Fi-Connected Instrument Oppenheimer, BTIG Initiate Coverage of MDxHealth at Outperform, Buy Top Five Articles on GenomeWeb Last Week: Invitae, Beckman Coulter, Ancient DNA, and More Radiomics, OncoDNA Partner to ID Lung Cancer Biomarkers The Scan Omicron's Emergence The World Health Organization has called Omicron a SARS-CoV-2 "variant of concern," the Los Angeles Times writes. Not as Much Merck's pill to treat COVID-19 reduces the risk of hospitalization and death among COVID-19 patients by less than previously reported, the New York Times says. Bats That Hang Together Discover magazine writes that researchers have found a social microbiome among vampire bats. PLOS Papers on CEWAS, Simian Varicella Virus Transcriptome, Dermatomyositis Markers In PLOS this week: multi-omic approach to home in on genetic risk variants, transcriptomic analysis of the simian varicella virus, and more.