ALK testing

Researchers identified unique ALK rearrangements in patients that lack previously known indicators of mesothelioma.

In head-to-head studies, a next-generation EGFR inhibitor and an ALK inhibitor beat their older counterparts in staving of cancer progression.  

The IHC test was used in clinical studies that led to Zykadia's approval last week as a first-line option for metastatic NSCLC patients with ALK rearrangements.

The expanded indication makes it a first-line option for metastatic non-small cell lung cancer patients with ALK rearrangements.

A big bump in service revenues made up for a decline in product revenues. The company also trimmed its operating expenses and narrowed its net loss. 

The non-small cell lung cancer drug now has two FDA-approved companion tests, Abbott's FISH test and Ventana's IHC test, for identifying patients most likely to benefit from treatment.

The partners will offer Horizon Discovery's reference materials as a standalone product to help validate ArcherDx's ALK fusion assays.

Ventana is providing ALK testing for clinical trials studying both Novartis' Zykadia and Genentech's alectinib.

Pfizer's Xalkori yielded significantly longer progression-free survival than standard chemotherapy in the Phase III trial of first-line treatment of ALK-positive NSCLC.

The company launched a blood-based diagnostic to guide treatment strategies for lung cancer patients with ALK fusions who don't have sufficient tumor biopsy material for analysis by tissue-based tests.

Pages

Using DNA to sketch crime victims might not be a great idea, the NYTimes says.

Science has its own problem with sexual harassment. What do we do with the research these abusers produce, Wired asks.

Senate Republicans led by Senator Rand Paul (R-KY) are trying to change how the government funds basic research, reports ScienceInsider.

In Science this week: combining genomics and ecology to better understand the effects of natural selection on evolution, and more.