This Week in Science

In Science this week, a group of Stanford University researchers present data pointing to an unexpectedly important role for RNA splicing in modulating phenotypic traits. In their study, the researchers quantified the contribution of cis-acting genetic effects at all major stages of gene regulation from chromatin to proteins, finding that splicing quantitative trait loci are "major contributors to complex traits," on par with variants that affect gene expression levels.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.