Skip to main content
Premium Trial:

Request an Annual Quote

This Week in Science: Feb 19, 2016

In this week's Science, the journal issues an erratum to the October 2015 report, "Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent." According to the notice, the paper's results were affected by a bioinformatics error that overestimated the geographic extent of the genetic impact of a historic migration into East Africa from Western Eurasia. The paper's conclusion that the migration occurred, specifically from a source genetically close to the early Neolithic farmers, was not affected. The Scan has more on this here.

And in Science Translational Medicine, a research team led by scientists from Hannover Medical School and Imperial College London suggests that a specific long, non-coding RNA (lncRNA) that appears to play a key role in heart failure could be a therapeutic target for the condition. The lncRNA, called Chast for cardiac hypertrophy–associated transcript, was found to be upregulated in mice with heart failure, while its overexpression triggered hypertrophic growth of heart muscle tissue in vitro. The group found that Chast was highly expressed in tissue from human hypertrophic hearts and that its suppression in mice could treat cardiac hypertrophy and improve heart function.