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In Science this week, a multi-institute team presents an RNA-sequencing analysis of more than 6,700 samples spanning 29 different normal tissues from roughly 500 people, finding that somatic mutations are present in nearly every tissue in the body. The researchers developed a computational pipeline — dubbed RNA-MuTect — that can detect somatic mutations from bulk RNA-seq data, and find that macroscopic clones can be found in many normal tissues.

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