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In Science this week, two research groups report data suggesting that cytosine base editors can trigger a significant number of off-target mutations. In the first paper, a group of US and Chinese scientists developed a method for detecting off-target mutations in mouse embryos following editing by either CRISPR-Cas9 or adenine or cytosine base editors.

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A new analysis suggests warming, not the arrival of humans, led to the extinction of the woolly rhinoceros thousands of years ago, the Economist reports.

Chinese health officials uncovered SARS-CoV-2 viral RNA on imported frozen food, but the New York Times reports catching COVID-19 that way would be unlikely.

The UK has ordered 60 million coronavirus vaccine doses from Novavax and 30 million doses from Janssen, according to the Guardian.

In Science this week: machine learning model predicts whether ion channel mutations will cause disease, and more.