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In this week's Science, Whitehead Institute researchers publish the results of a CRISPR-Cas9 screen identifying the protein sideroflexin 1 as a requisite component of one-carbon metabolism — a process in which the amino acid serine is used by the cell to generate one-carbon units required for metabolite synthesis. The screen was designed to find genes related to serine transport and identified sideroflexin 1 as the main mitochondrial serine transporters in human cells.

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