This Week in Science

In Science this week, two groups publish studies offering clues about the genetics behind cancer susceptibility to immune checkpoint inhibition. In the first, researchers used CRISPR screening on a mouse melanoma cell line resistant to immune checkpoint inhibitors to identify several genes whose inactivation enhanced tumor sensitivity to such drugs, including three — Pbrm1, Arid2, and Brd7 — that produce proteins part of a chromatin remodeling complex.

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The New York City medical examiner is overseeing an effort to identify missing persons using DNA, according to the Associated Press.

Nobel laureate Günter Blobel has died at 81, the New York Times reports.

In PNAS this week: mouse model of genetically induced emphysema, gene expression signatures of circulating melanoma cells, and more.

Technology Review reports that 2017 was the year of consumer genetic testing and that it could spur new analysis companies.