This Week in Science

In Science this week, a multi-institute research team reports a study establishing that tumors with defects in a genome maintenance pathway called mismatch repair (MMR) are highly responsive to a certain type of immunotherapy. Building off of a previous study that showed colorectal cancers with MMR deficiency were sensitive to immune checkpoint blockade with anti-PD-1 antibodies, the scientists analyzed 86 patients with 12 different MMR-deficient tumor types in an ongoing clinical trial.

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360Dx reports that the US Centers for Medicare & Medicaid Services would cover next-generation sequencing-based cancer panel tests.

The Washington Post reports that a meteorologist is being considered as presidential science and technology advisor.

In PNAS this week: precision medicine strategy to screen for disease risk, genome evolution in Haemophilus influenzae, and more.

Researchers have developed a PCR-based assay to gauge whether manatees are present in waters.