This Week in PNAS

In the early, online edition of the Proceedings of the National Academy of Sciences, a Johns Hopkins University-led team characterizes rare somatic mutations in genomic and mitochondrial DNA from normal human tissues using a massively parallel, barcoded sequencing method called the bottleneck sequencing system (BotSeqS), which involves a dilution step prior to DNA amplification.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.