This Week in PNAS

In the early, online edition of the Proceedings of the National Academy of Sciences, an international team led by investigators in Singapore and the US presents results from a mutagenesis screen intended to root out mutations that contribute to gastric cancer development in mice missing one copy of the tumor suppressor gene Smad4.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.