This Week in PNAS

In the early, online edition of the Proceedings of the National Academy of Sciences, researchers from Harvard Medical School and New York University present findings from a candidate gene-based search for genetic factors that allow Mexican cavefish to survive in food-poor environments. The team performed targeted sequencing on genes suspected of contributing to metabolism, comparing cave-dwelling forms of the species with those residing in surface waters.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.