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Researchers from China and the US explore and edit epigenetic patterns in individual mammalian egg cells from mouse models. Using single-cell bisulfite sequencing, the team demonstrated that cytosine methylation patterns in first polar body cells (PB1) can be used to assess methylation patterns in corresponding single cells, before going on to edit methylation marks related to mouse coat color or methylation marks related to familial Angelman syndrome in humans.

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