This Week in PNAS

In the early, online edition of the Proceedings of the National Academy of Sciences, researchers from the Universities of Virginia and Massachusetts present a strategy for reactivating MECP2 — the X-linked gene that undergoes loss-of-function mutation in the neurodevelopmental condition called Rett syndrome — from the inactive X chromosome in human cell lines and mouse models.

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Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.

The New York Times reports that evidence linking trauma in one generation to epigenetic effects that influence subsequent generations may be overstated.

ScienceInsider reports that US National Institutes of Health researchers were told in the fall they could not obtain new human fetal tissue.

In PNAS this week: skin pigmentation evolution among KhoeSan, biomarkers for dengue virus progression, and more.