This Week in PNAS

A University of Oxford-led team takes a look at the relationship between genotype and insecticide resistance phenotypes in the Anopheles gambiae mosquito as part of a broader study quantifying insecticide resistance patterns in the African malaria vector. The researchers sampled An. gambiae from nearly 1,200 sites in Africa, profiling insecticide resistance and using a geostatistical modeling approach to consider co-variation in resistance to multiple insecticides.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.