This Week in PNAS

In the early, online edition of Proceedings of the National Academy of Sciences, investigators from the University of Massachusetts and Tufts University demonstrate the feasibility of establishing a mouse model of genetically-induced emphysema using CRISPR/Cas9-based editing to lop out half a dozen paralogs of Serpina1 — a gene implicated in alpha-1 antitrypsin deficiency (AAT)-related forms of emphysema in humans.

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NPR reports that researchers in Italy are testing a gene drive aimed at controlling mosquito populations.

Researchers may experience the effects of the government shutdown for a while, the Los Angeles Times reports.

A new study finds that the majority of patients at a Tijuana clinic received a diagnosis after first-line genome sequencing, the San Diego Union-Tribune reports.

In Genome Biology this week: post-transcriptional modification-based stratification of glioblastoma, single-cell analysis of gene expression and methylation in human iPSCs, and more.