In the Proceedings of the National Academy of Sciences, researchers from the US and Finland explore the role that amplifications of the oncogene Akt3 play in the progression of the brain cancer glioma. After detecting amplifications of Akt3, Akt2, and Akt1 in several cancer types — including the most common form of glioma, called glioblastoma — the researchers tracked glioma progression and gene expression profiles in mouse models of glioma that harbored various Akt isoforms.