This Week in PNAS

In the early, online edition of the Proceedings of the National Academy of Sciences, a team from Japan and the US describe recurrent deletions involving a portion of chromosome 3 in individuals with mesothelioma. Using a custom array comparative genomic hybridization array, the researchers assessed nearly three dozen malignant mesothelioma biopsy samples, searching for copy number changes affecting the chromosome 3p21 region — a site containing more than 250 genes.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.