This Week in PNAS

In the early, online edition of the Proceedings of the National Academy of Sciences, researchers from Spain, Germany, Japan, and Brazil describe a long non-coding RNA that assists in TP53 tumor suppressor activity, but is inactivated by hypermethylation in some cancer. The team did array-based methylation profiling in colon cancer cell lines with or without disrupted methyltransferase enzymes, along with normal colon mucosa.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.