This Week in PLOS

In PLOS Genetics, French and American researchers describe computational efforts to rank the accuracy of functional assays used to classify genetic variants for clinical decision making after targeted-, exome-, or whole-genome sequencing. The team focused on findings from four yeast cell-based functional assays aimed at classifying dozens of variants in BRCA1, a gene that contains variants implicated in enhanced risk of breast and/or ovarian cancer.

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Berkeley researchers have engineered yeast to make the molecule behind the hoppy taste of beer, Quartz reports.

King's College London researchers examine the influence of school type and genetics on academic achievement.

FiveThirtyEight writes that most who take a direct-to-consumer BRCA1/2 genetic test won't learn much from it.

In Science this week: early life experience influence somatic variation in the genome, and more.