This Week in PLOS

In PLOS Genetics, researchers from the University of Helsinki and elsewhere report on findings from an exome sequencing analysis of small bowel adenocarcinoma. The team used a combination of exome sequencing and OncodriveFML driver mutation detection analysis to profile more than 100 primary small bowel adenocarcinoma samples archived over several years, from 2003 to 2011.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.