This Week in PLOS

In PLOS Genetics, a Columbia University-led team takes a look at a case-control gene-based collapsing approach for uncovering de novo mutations involved in epileptic encephalopathy. Focusing on very rare variants in protein-coding genes from 488 individuals with epileptic encephalopathy and 12,151 without, the researchers narrowed in on so-called qualifying variants that appeared to have pronounced effects on epileptic encephalopathy.

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What happens to scientific papers when certain journals are no longer published? Some scientists are trying to make sure they don't disappear forever.

A study in Microbiome finds that heavy drinkers have an unhealthy mix of bacteria in their mouths.

Doctors and patients are still trying to figure out what role at-home genetic testing should play in healthcare, Newsweek says.

In Genome Research this week, mismatch repair deficiency in C. elegans, retracing transcriptions start site evolution in the human genome, and more.