This Week in PLOS

In PLOS One, a team from Taiwan and Singapore explores the effectiveness of an 18-gene classifier for predicting distant metastasis in individuals with breast cancer. The researchers applied the algorithm — initially established to predict local progression or regional recurrence — to fresh-frozen primary breast tumor samples from 683 individuals with breast cancer, including 101 individuals who experienced metastasis and 583 who were metastases-free.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.