This Week in PLOS

In PLOS One, a team from Taiwan and Singapore explores the effectiveness of an 18-gene classifier for predicting distant metastasis in individuals with breast cancer. The researchers applied the algorithm — initially established to predict local progression or regional recurrence — to fresh-frozen primary breast tumor samples from 683 individuals with breast cancer, including 101 individuals who experienced metastasis and 583 who were metastases-free.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.