This Week in PLOS

In PLOS Genetics, researchers from Yale University, Peking University, and the University of Washington report on findings from a study suggesting ties between immune-related DNA elements and susceptibility to late-onset Alzheimer's disease. The team began by using a statistical framework called GenoSkyline-Plus to narrow in on tissue-specific regulatory clues to complex conditions based on data from epigenetic and genome-wide association studies.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.