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Scientists at the University of Edinburgh have found that the DISC1 gene affects how patients with schizophrenia respond to treatment. Their work was published in PLoS One this week. Looking across public datasets, they found correlations between variants in the DISC1 pathway genes and levels of gene expression, and that variants of DISC1, NDE1, PDE4B, and PDE4D regulate the expression of cytoskeletal, synaptogenic, neurodevelopmental, and sensory perception proteins.

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