Italian researchers introduce a tool called EXCAVATOR2 that's designed to dig up copy number variants that would otherwise be missed from whole-exome sequence data. The read count-based tool takes advantage of both in- and off-target regions of the exome, providing a look at the portions of the genome not targeted by exome capture. The team applied the approach to exome data from the 1000 Genomes Project and exome sequences from 14 individuals with bladder cancer.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.