Italian researchers introduce a tool called EXCAVATOR2 that's designed to dig up copy number variants that would otherwise be missed from whole-exome sequence data. The read count-based tool takes advantage of both in- and off-target regions of the exome, providing a look at the portions of the genome not targeted by exome capture. The team applied the approach to exome data from the 1000 Genomes Project and exome sequences from 14 individuals with bladder cancer.

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