Researchers from the University of Bergen and Harvard University outline updates to the web tool CHOPCHOP, which is designed to guide CRISPR- and TALEN-based genome engineering efforts. Version two of the database is decked out with new tools to support updated CRISPR approaches, including those that involve Cpf1 and Cas9 nickase enzymes, the team notes, while allowing for custom length single-guide RNAs.

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