An Italian team has characterized the microRNA repertoire in human retinas using deep, small RNA sequencing on retina samples from 16 individuals and two human retinal pigment epithelium/choroid tissue samples. The researchers estimated that the resulting retinal miRNome encompasses some 90 percent of the miRNAs expressed in the retina, including more than four dozen retina-specific miRNA candidates and thousands of isomiRs, or miRNA variants.

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While gene therapies may have high price tags, they could be cheaper than the cost of managing disease, according to MIT's Technology Review.

Researchers are looking for markers that indicate which cancer patients may respond to immunotherapies, the Associated Press writes.

In Nature this week: paternal age associated with de novo mutations in children, and more.

Nature News writes that researchers are still wrangling over the role of the p-value.