This Week in Nature

Dec 18, 2014

In Nature Biotechnology this week, a team from Boston Children's Hospital describes a new genome-wide method for detecting DNA double-strand breaks generated by engineered nucleases. By combining high-throughput, genome-wide translocation sequencing with different CRISPR/Cas9 and TALEN gene-editing nucleases, the researchers identified off-target hotspot numbers for the given nucleases and extended the number of known off-targets for certain previously characterized nucleases.

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The Scan

Best Options

The Seattle Times writes that pharmacogenomics testing can help choose medications that may work best for people with depression.

A Butterfly's Wings

Researchers report that deleting one gene from butterflies affects their wing coloration patterns, according to the Washington Post.

This Week in PNAS

In PNAS this week: genome sequencing of weevil symbionts, retinoid X receptor deletion in lung cancer metastasis, and more.

Pathogen Tracking

Sequencing could help combat foodborne illnesses, according to a blog post by Food and Drug Administration officials.

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