This Week in Nature

In Nature Biotechnology this week, a team from Boston Children's Hospital describes a new genome-wide method for detecting DNA double-strand breaks generated by engineered nucleases. By combining high-throughput, genome-wide translocation sequencing with different CRISPR/Cas9 and TALEN gene-editing nucleases, the researchers identified off-target hotspot numbers for the given nucleases and extended the number of known off-targets for certain previously characterized nucleases.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.