This Week in Nature

In Nature Methods this week, the journal names single-particle cryo-electron microscopy (cryo-EM) as the Method of the Year 2015, citing its ability to determine difficult protein and protein-complex structures at high resolution. Unlike x-ray crystrallography, cryo-EM does not require the time-consuming step of protein crystallization and can be applied to large and structurally diverse protein complexes.

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A federal grand jury has indicted Elizabeth Holmes and Ramesh Balwani for alleged wire fraud in conjunction with their activities at Theranos.

Nature News reports that some developers are nervous about GitHub's acquisition by Microsoft.

A direct-to-consumer genetic testing company sent out used spit kits, CNBC reports.

In PLOS this week: comparison of commercial bisulfite kits, new method to predict essential proteins, and more