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This Week in Nature

In this week's Nature, University of California, Berkeley, researcher and CRISPR/Cas9 pioneer Jennifer Doudna and colleagues present data giving new insights into how the genome-editing technology zeroes in on its target. They found that the conformational state of the nuclease domain that cleaves target DNA strands directly controls the cutting activity. The discovery highlights a "proofreading mechanism" that serves as a final checkpoint before DNA double-strand break formation.

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Matt Hancock, the UK health secretary, is calling for the swift rollout of predictive genetic tests, the Guardian reports.

A WHO panel is calling for a global registry of human germline gene-editing projects, according to Stat News.

Vox writes that lab mishaps involving pathogens are quite common.

In Genome Biology this week: analysis of wild and cultivated peach genomes, Hi-C-based pipeline for assembling microbial genomes from metagenomic data, and more.