This Week in Nature

In this week's Nature, University of California, Berkeley, researcher and CRISPR/Cas9 pioneer Jennifer Doudna and colleagues present data giving new insights into how the genome-editing technology zeroes in on its target. They found that the conformational state of the nuclease domain that cleaves target DNA strands directly controls the cutting activity. The discovery highlights a "proofreading mechanism" that serves as a final checkpoint before DNA double-strand break formation.

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The US National Institutes of Health and the Food and Drug Administration have proposed changing gene therapy oversight, the Associated Press reports.

Nature News reports that the Salk Institute has asked for the scope of a gender discrimination lawsuit brought against it to be narrowed.

CNBC reports that the sequencing startup Veritas aims to sequence individuals who fall at extremes.

In PLOS this week: genotyping of indigenous North African goats, program to simulate evolve and resequencing studies, and more.