This Week in Nature

In Nature this week, a University of Washington team reports on the use of saturation genome editing to evaluate the function of nearly 4,000 single-nucleotide variants (SNVs) across 13 exons that are critical to the function of the tumor-suppressor gene BRCA, and measure subsequent cell survival in haploid human cells. They identify more than 400 non-functional missense SNVs, as well as roughly 300 SNVs that disrupt expression.

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Consulting company McKinsey says diagnostics companies will have to combine genomic data analysis, electronic medical records, effective reimbursement strategies, and regulatory compliance in order to win.

A new report has found that researchers in Africa are still heavily dependent on funding from organizations in the US, Europe, and China, Nature News says.

An article in The Atlantic argues that the progress being made in science isn't keeping pace with the money and time being spent on research.

In Science this week: a CRISPR screen identifies sideroflexin 1 as a requisite component of one-carbon metabolism, and more.