This Week in Nature

In Nature this week, a University of Washington team reports on the use of saturation genome editing to evaluate the function of nearly 4,000 single-nucleotide variants (SNVs) across 13 exons that are critical to the function of the tumor-suppressor gene BRCA, and measure subsequent cell survival in haploid human cells. They identify more than 400 non-functional missense SNVs, as well as roughly 300 SNVs that disrupt expression.

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NPR reports that researchers in Italy are testing a gene drive aimed at controlling mosquito populations.

Researchers may experience the effects of the government shutdown for a while, the Los Angeles Times reports.

A new study finds that the majority of patients at a Tijuana clinic received a diagnosis after first-line genome sequencing, the San Diego Union-Tribune reports.

In Genome Biology this week: post-transcriptional modification-based stratification of glioblastoma, single-cell analysis of gene expression and methylation in human iPSCs, and more.