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This Week in Nature: Jun 22, 2017

In this week's Nature Genetics, an international research team presents the discovery of genetic variants within a fetus' genome that influence the risk of preeclampsia in the mother. The scientists performed a genome-wide association study of children of preeclamptic pregnancies and found two novel variants near the FLT1 gene that were significantly associated with the condition. Notably, FLT1 encodes a receptor mediating the formation of new blood vessels, and previous studies have implicated a form of this receptor in preeclampsia pathology. GenomeWeb has more on this, here.

Also in Nature Genetics, a Decode Genetics team publishes a study identifying a new gene associated with psychosis. They used whole-genome sequencing and long-range phasing to study a family in Iceland with 10 members who have experienced symptoms of psychosis, and discovered a disrupting mutation in the RBM12 gene in all the affected individuals. A different RBM12 mutation was also found in a family in Finland with members who had experienced psychosis, providing strong evidence of a link between the gene and the disorder. GenomeWeb also covers this, here.


The Scan

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.

Topical Compound to Block EGFR Inhibitors May Ease Skin Toxicities, Study Finds

A topical treatment described in Science Translational Medicine may limit skin toxicities seen with EGFR inhibitor therapy.

Dozen Genetic Loci Linked to Preeclampsia Risk in New GWAS

An analysis of genome-wide association study data in JAMA Cardiology finds genetic loci linked to preeclampsia that have ties to blood pressure.

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.