This Week in Nature

In this week's Nature, a multi-institute team of scientists describes the use of reverse genetics to determine the phenotypes of loss-of-function mutations, setting the stage for a "human knockout project" to understand the phenotypic consequences of complete disruption of genes. The researchers sequenced the gene-coding regions of more than 10,000 Pakistani individuals, identifying nearly 50,000 mutations predicted to cause loss of function in 1,317 genes.

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A research duo estimates in PLOS One the number of papers that have used misidentified cell lines.

UK's National Institute for Health and Care Excellence approves GlaxoSmithKline's SCID gene therapy despite cost.

Science reports that Brazilian researchers are petitioning for the reversal of budget cuts.

In PLOS this week: gene flow patterns in common ash, guidelines for using morpholinos in zebrafish, and more.