Long noncoding RNAs play a key role in regulating gene expression in embryonic stem cells, researchers from Cold Spring Harbor Laboratory and Isis Pharmaceuticals report in Genome Research. The researchers turned to high-depth poly(A)+ RNA sequencing of mouse embryonic stem and neural progenitor cells to uncover differentially regulated lncRNA.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.