A UK team takes a look at mutational signatures associated with DNA mismatch repair deficiency in the Caenorhabditis elegans worm model organism and in human tumor samples. The researchers used mutation accumulation assays and genome sequencing to follow the genetic alterations that accumulated in C. elegans worms missing the DNA mismatch repair genes PMS2 and MLH1 and/or the polymerase subunit-coding gene POLE4.

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