Researchers from Yonsei University and other centers in Korea search for guide RNAs to target specific KRAS mutations in cancer cells using the CRISPR-Cas9 genome-editing approach. After screening for effective KRAS-editing guide RNAs in a cell line containing a fluorescent reporter system, the team validated the most promising guide RNAs in cancer cell lines with wild type KRAS or versions of the gene containing mutations of interest.

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