Investigators from Albert Einstein College of Medicine and elsewhere describe hydroxymethylation shifts at sites in the pancreatic cancer genome with regulatory roles related to oncogenic processes. Using approaches such as hmC-seal 5'-hydroxymethylation enrichment, bisulfite sequencing, ATAC-seq, and RNA-seq, the team tracked patterns for 5'-hydroxymethylation and cytosine methylation in pancreatic cancer cell lines, patient-derived xenograft tumors, and cancer-free pancreatic samples.

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