Korean and American researchers take a look at intra-tumor heterogeneity using single-cell RNA sequencing for a study appearing online in Genome Biology. The team did single-cell messenger RNA sequencing on nearly three dozen cells isolated from a xenograft derived from tumor sample taken from an individual with lung adenocarcinoma. In the process, the investigators uncovered four lung cancer sub-clones with different gene mutations, drug resistance profiles, and prognostic gene expression patterns.

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