This Week in Cell

Researchers from the Netherlands, the US, and the UK share details about the method they used to establish and start characterizing a biobank of organoids from individuals with colorectal cancer. After developing 22 tumor and 19 matched normal organoids with samples from 20 colorectal cancer patients, they used whole-exome sequencing, array-based gene expression profiling, viability assays, and other approaches to compare features in the organoids with those found in the tissues used to develop them.

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The UK's Nuffield Council on Bioethics says genetically modifying human embryos could be morally permissible, according to the Guardian.

A new Nature Biotechnology paper reports that CRISPR-Cas9 gene editing can lead to large deletions or complex rearrangements that could be pathogenic.

The Wall Street Journal likens a prototype developed by Synthetic Genomics to a "biological fax machine."

In PNAS this week: strategy for reactivating Rett syndrome-linked MECP2, small molecules able to suppress Staphylococcus aureus virulence, and more.