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A Memorial Sloan Kettering-led team tracks tumor genomic changes in individuals with advanced melanoma receiving the anti-PD-1 immune checkpoint treatment nivolumab. Using a combination of exome sequencing, transcriptome sequencing, and T-cell receptor sequencing, the researchers characterized tumor and microenvironment features before and after nivolumab treatment in 68 advanced melanoma patients, including 33 individuals who had already progressed on the CTLA-4-targeting drug ipilimumab.

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The University of California, Berkeley's Jennifer Doudna reflects at Science on the anniversary of the announcement of the birth of twin girls who underwent genome editing.

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