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A Northwestern University-led team takes a look at potential strategies for targeting forms of leukemia with translocations involving the MLL gene. Based on RNA sequencing analyses, small hairpin RNA screening, and other experiments on leukemic cell lines, the researchers suggest that there may be a therapeutic benefit to stabilizing wild-type MLL via the UBE20 ubiquitin ligase enzyme and the interleukin-1 pathway in leukemias with MLL rearrangements.

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