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Unique Germline Variants Found Among Black Prostate Cancer Patients

In a study appearing in JCO Precision Oncology, researchers uncovered more than two dozen unique pathogenic or likely pathogenic variants within a cohort of Black prostate cancer patients. The Duke University School of Medicine-led team performed whole-exome sequencing of a population-based cohort of 743 Black prostate cancer patients, all of whom had been diagnosed with the disease at 62 years of age or younger. Within 30 men, they found 26 unique pathogenic or likely pathogenic variants in more than a dozen genes, including HOXB13, BRCA1, BRCA2, BRIP1, ATM, CHEK2, and PALB2. Additionally, they identified within 39 men 33 unique variants of unknown significance within 16 genes. The researchers note that most individuals with these germline variants were more likely to have a relative who had been diagnosed with DNA damage repair, or DDR, gene-related cancer. "Variants in DDR genes and HOXB13 may be important cancer risk factors for Black men diagnosed with early-onset prostate cancer, and are more frequently observed in men with a family history of cancer," the researchers write.

The Scan

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.

Sequencing Study Leads to Vaccine Target in Bacteria Behind Neonatal Meningitis

Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal meningitis in mouse models of the disease.

Multiple Myeloma Progression Influenced by Immune Microenvironment Expression

Researchers in NPJ Genomic Medicine compare RNA sequencing profiles of 102,207 individual cells in bone marrow samples from 18 individuals with rapid or non-progressing multiple myeloma.

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.