Skip to main content
Premium Trial:

Request an Annual Quote

UCLA Team Maps Mitochondrial Networks in Non-Small Cell Lung Cancer

Using a combination of different cutting-edge imaging technologies, scientists from the University of California, Los Angeles have generated three-dimensional ultra-resolution maps of mitochondrial networks in lung tumors, revealing new details about their role in non-small cell lung cancer (NSCLC). Mitochondria play an important role in metabolism and bioenergetics in cancer cells, but little is known about the structural organization of mitochondrial networks and their bioenergetic activity at the in vivo level. In their study, which appears in Nature this week, the researchers use an integrated platform consisting of positron emission tomography imaging, respirometry, and 3D scanning block-face electron microscopy to analyze mitochondrial networks and bioenergetic phenotypes across mouse and human NSCLC tumors. They find that within the two primary subtypes of NSCLC — adenocarcinoma and squamous-cell carcinoma — mitochondrial networks are compartmentalized into distinct subpopulations that govern the bioenergetic capacity of the different tumors. As such, defining the relationship between mitochondrial architecture and a tumor's metabolic dependencies may help develop diagnostic and therapeutic strategies that can be leveraged to exploit bioenergetic and metabolic liabilities unique to lung cancer subtypes, the study's authors write.

The Scan

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.

Acne-Linked Loci Found Through GWAS Meta-Analysis

Researchers in the European Journal of Human Genetics find new and known acne vulgaris risk loci with a genome-wide association study and meta-analysis, highlighting hair follicle- and metabolic disease-related genes.

Retina Cell Loss Reversed by Prime Editing in Mouse Model of Retinitis Pigmentosa

A team from China turns to prime editing to correct a retinitis pigmentosa-causing mutation in the PDE6b gene in a mouse model of the progressive photoreceptor loss condition in the Journal of Experimental Medicine.

CRISPR Screens Reveal Heart Attack-Linked Gene

Researchers in PLOS Genetics have used CRISPR screens to home in on variants associated with coronary artery disease that affect vascular endothelial function.