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Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Reporting in the JAMA Network Open, investigators at the London School of Economics and Political Science, the University of Pittsburgh, and the University of California at San Diego explore the relationship between treatment costs and the research and development inputs that when into the corresponding drugs, focusing on 60 drugs approved by the US Food and Drug Administration over nearly a decade between early 2009 and the end of 2018. The team's modeling analyses did not support the notion that research and development investments track with the ultimate cost of a drug and found no clear association between these variables. Instead, the results suggest that "there was no association between estimated research and development investments and treatment costs based on list prices at the launch of the product or based on net prices a year after launch," the authors argue, adding that "drug companies should make further data available if they want to use this argument to justify high prices."

The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.