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Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

In Science Advances, a team from Australia and the Netherlands follows the epigenetic and other effects of the tuberculosis-targeting Bacille Calmette-Guérin (BCG) vaccine in an in vitro trained immunity model and in peripheral blood monocyte samples collected from 130 BCG-vaccinated or unvaccinated infants. With a combination of RNA sequencing, chromatin immunoprecipitation sequencing, array-based methylation profiling, RNA editing, expression quantitative trait locus mapping, and other approaches, the researchers saw viral response-related interferon (IFN)-related response to BCG vaccination, along with circulating monocyte DNA methylation shifts that persisted over time. "[W]e identify a BCG-associated DNA methylation signature that persisted more than 12 months after neonatal BCG vaccination," the authors report, noting that "[g]enes associated with this epigenetic signature are involved in viral response pathways, consistent with the reported off-target protection against viral infections in neonates, adults, and the elderly."

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.